What is it about?
Dietary methionine restriction slows down cancer progression by inhibiting the cell cycle by increasing cell cycle inhibitors, CDKN1a (P21) and CDKN1b (P27) in a xenograft mouse model.
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Why is it important?
The concept of dietary intervention as a combined treatment with chemotherapy or immunotherapy can improve a patients outlook. Dietary methionine restriction has already been shown to improve healthspan by improving metabolism and reducing body fat in mice. The affects of methionine restriction are probably universal, since many different organisms( yeast, flies, mammalian (mice, rats, humans)), can be affected by it.
Perspectives
Although methionine restriction is not the cure-all for cancer, it can be a beneficial treatment in conjunction with other cancer therapies. Further, there is a lot that is not known about how methionine restriction affects the cells. Unpublished and published data from my lab has demonstrated that epigenetic mechanisms via miRNAs are altered in the different organs of mice on a methionine restricted diet. Further understanding of the mechanisms involved in methionine restriction phenomena is needed.
Dr julie r hens
OFAS
Read the Original
This page is a summary of: Erratum to: Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice, BMC Cancer, July 2016, Springer Science + Business Media,
DOI: 10.1186/s12885-016-2404-0.
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