What is it about?
The interferon tau exposed transcriptome changes found in the CL of day 18 pregnant and non-pregnant cows using RNA-Seq. The majority of the changes that occur in vivo are supported by in vitro luteal cells exposed to recombinant ovine interferon tau.
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Why is it important?
This is one of the first studies that unraveled the unique transcriptomic signature of the IFNT-exposed, early pregnancy corpus luteum, highlighting the abundance of downregulated pathways known to be otherwise induced during luteolysis. These and IFNT-regulated in vitro pregnancy-specific DEGs suggest that IFNT contributes to the characteristics and maintenance of early pregnancy corpus luteum.
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This page is a summary of: Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro, BMC Genomics, June 2021, Springer Science + Business Media,
DOI: 10.1186/s12864-021-07747-3.
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