Impact of hormonal stimulation and in vitro procedures on DNA during early stages of development.

What is it about?

DNA methylation is an important modification to the genome in the early stages of mammalian development. DNA methylation patterns in the sperm and oocyte are crucial for successful embryo development. This work shows that DNA methylation is altered when oocytes are superovulation-derived and when fertilisation and embryo culture occur outside of the body.

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Why is it important?

Our findings highlight the importance of studying the impact of assisted reproduction techniques in bovine embryo production systems. These findings are very useful for comparative studies in human.