What is it about?
FASTCORMICS allows building metabolic model out of transcriptomic data in few minutes. The metabolic model were then used as scaffold for the integration of super-enhancer that we showed to control the flux distribution through the tight regulation of entry points and transporters
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Why is it important?
Fastcormics allows the building of metabolic model via the integration of microarray data that outperforms other algorithms in speed without loss of quality of the reconstruction. The study allows understand the role of super-enhancers on the metabolism of macrophage
Read the Original
This page is a summary of: Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network, BMC Genomics, October 2015, Springer Science + Business Media,
DOI: 10.1186/s12864-015-1984-4.
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Resources
Fast reconstruction of compact conext-specific metabolic network models
FASTCORE vanilla version of a family of algorithms that allows the metabolic version in the time frame of seconds to few minutes.
Visulization of the differentition of monocytes to macrophage from a metabolic modelling point of view
Visualiyation of the differentiation from monocytes to macrophage. Metabolic Models were build using the FASTCORMICS workflow and visualized using the shiny R package.
Contributors
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