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Why is it important?
Sensory neurons with A-delta axons are often associated with pain, nociception and TRPV1 receptors. This study indicates that despite their thinly myelinated axons, regularly discharging aortic baroreceptors lack TRPV1, a finding which reinforces the TRPV1+ and TRPV1- dichotomy of cranial visceral afferents.
Perspectives
While a negative result, this work fits into a much broader narrative of TRPV1 agonist responses in Xth cranial nerve physiology including their central transmission within the solitary tract nucleus in the brainstem.
Michael C. Andresen
Oregon Health and Science University
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This page is a summary of: Capsaicin- resistant arterial baroreceptors, Journal of Negative Results in BioMedicine, May 2006, Springer Science + Business Media,
DOI: 10.1186/1477-5751-5-6.
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