MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1

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Why is it important?

The significance of our study is that we demonstrated for the first time that the expression of an important oncogene BMI-1 was suppressed by miR-194 at the post-transcriptional level in endometrial cancer. The suppression of BMI-1 by miR-194 is essential in regulating epithelial-mesenchymal transition of endometrial cancer cells. These results provide a critical foundation for developing future therapeutic strategy to effectively suppress human cancer metastasis by targeting BMI-1 using miR-194 or small molecule mimics.