Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition

What is it about?

Analysis of eukaryotic gene expression profiles during Shigella infection in the presence and absence of an apoptosis inducer.

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Why is it important?

Shigella inhibits apoptosis or cell death in epithelial cells. This analysis demonstrates how Shigella infection results in an induced pro-survival state of epithelial cells, which enables Shigella to establish a replicative niche inside the host.