What is it about?
In this study, we attempt to develop effervescent tab- lets of levetiracetam using water-soluble excipients. The present work holds the advantage of both tablet and li- quid dosage form and also helps to overcome the prob- lem encountered in oral tablet and liquid dosage forms. The present study can also be used as an alternative manufacturing process of 3D printing process employed in SPRITAM® tablet. In the present investigation, RSM was utilized to design and optimize the effervescent for- mulation of levetiracetam, and the effects of “acid: base” couple was accessed on effervescent time, friability, and hardness.
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Why is it important?
The uniqueness of this publication is, it utilized water soluble excipients and uses orange flavors which make it patient friendly specifically paedriatic and xeriartic patients.
Perspectives
For acceptance of children and elderly people, the bitter taste of the formulation was enhanced by using aspartame and orange flavor in a suitable concentration. The study demonstrated that CCRD with RSM is a systematic optimization approach which could be effectively used to study the inter-relationships of studied variables.
Dr Abikesh Prasada Kumar Mahapatra
Read the Original
This page is a summary of: Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam, Future Journal of Pharmaceutical Sciences, November 2020, Springer Science + Business Media,
DOI: 10.1186/s43094-020-00096-0.
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