What is it about?

The development of the neonatal abstinence syndrome core outcome set in five stages including interviews with parents/families; a systematic review; Delphi survey to gain expert opinion on the importance of health outcomes influencing NAS management decision; a consensus meeting to finalize the items and implementation planning.

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Why is it important?

The prevalence of neonatal abstinence syndrome (NAS) is increasing globally resulting in an increased incidence of adverse neonatal outcomes and health system costs. Evidence regarding the effectiveness of NAS prevention and management strategies is very weak and further research initiatives are critically needed to support meta-analysis and clinical practice guidelines. In NAS research, the choice of outcomes and the use of valid, responsive and feasible measurement instruments are crucial. There is currently no consensus and evidence-based core outcome set


Membership of an international Multidisciplinary Steering Committee to develop core outcome set for management strategies in neonatal abstinence syndrome.

Dr Sonya MacVicar
Edinburgh Napier University

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This page is a summary of: Outcome reporting in neonates experiencing withdrawal following opioid exposure in pregnancy: a systematic review, Trials, March 2020, Springer Science + Business Media, DOI: 10.1186/s13063-020-4183-9.
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