What is it about?
We demonstrated that these differences are aggregated into contiguous regions and are conserved between different tissues in the body. This implies that chromosome accessibility is established early in human development and is maintained even as new types of cells develop.
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Why is it important?
Despite constant changes in function and shape of chromosomes within the cell cycle and during development of different cell types, new generations of cells are able to accurately re-establish cell (or functional) programming consistent with that of parent cells. The understanding of this mechanism remains incomplete. Epigenetic memory has been suggested as one mechanism to regenerate the same genome and epigenome organization in cell progeny. The conservation of chromosomal accessibility in dividing cells may be the biomarker of epigenetic memory.
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This page is a summary of: Differentially accessible, single copy sequences form contiguous domains along metaphase chromosomes that are conserved among multiple tissues, Molecular Cytogenetics, October 2021, Springer Science + Business Media, DOI: 10.1186/s13039-021-00567-w.
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