What is it about?

The interferon tau exposed transcriptome changes found in the CL of day 18 pregnant and non-pregnant cows using RNA-Seq. The majority of the changes that occur in vivo are supported by in vitro luteal cells exposed to recombinant ovine interferon tau.

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Why is it important?

This is one of the first studies that unraveled the unique transcriptomic signature of the IFNT-exposed, early pregnancy corpus luteum, highlighting the abundance of downregulated pathways known to be otherwise induced during luteolysis. These and IFNT-regulated in vitro pregnancy-specific DEGs suggest that IFNT contributes to the characteristics and maintenance of early pregnancy corpus luteum.


We hope this work gives more strength to the notion that interferon tau endocrine actions are necessary to maintain the functional corpus luteum which a prerequisite for the successful establishment of early embryonic development. By writing this article we initiated a global collaboration and it created an opportunity o work together with people from different backgrounds.

Mr Raghavendra Basavaraja
University of Texas Southwestern Medical Center

Read the Original

This page is a summary of: Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro, BMC Genomics, June 2021, Springer Science + Business Media,
DOI: 10.1186/s12864-021-07747-3.
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