Prevalence and genetic basis of first-line drug resistance ofMycobacterium tuberculosisin Ca Mau, Vietnam

What is it about?

Tuberulosis is a major cause of morbidity and mortality world wide with drug resistance being a major threat to effective tuberculosis management. This study examines the genotypic and phenotypic profile of tuberculosis in Vietnam. It found that 19.8% of cases of Tuberculosis were resistant to the first line drug isoniazid and that mutation to the KatG gene was most common cause of resistance. This study helps understand the challenges facing Tuberculosis control in Vietnam and is the first of it's kind to be conducted with active case finding, thus reducing the selection bias of passive resistance profiling.

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