What is it about?
The clinical decision to optimize aerosol delivery is often arbitrary and the exact drug dosages are used with all nebulizers and patients. We have shown for the first time delivered dose differed based on nebulizer type and patient populations.
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Why is it important?
Many patients transition between spontaneous breathing, noninvasive ventilation, and mechanical ventilation. Although aerosol therapy is done based on the clinician’s judgment/experience, it is not individualized based on the patient’s needs and the nebulizer used for therapy. While the same drug dosages are used for all patient populations and nebulizers, there are no reports that compared the delivery efficiency of jet and mesh nebulizers between various modes of ventilation.
Perspectives
Understanding differences in delivery efficiency between mechanical ventilation, noninvasive ventilation, and spontaneous breathing could provide guidance as to how to adjust doses between types of ventilation to improve consistent targeted drug delivery to the lungs of patients.
Arzu Ari
Texas State University San Marcos
Read the Original
This page is a summary of: Delivered dose with jet and mesh nebulisers during spontaneous breathing, noninvasive ventilation and mechanical ventilation using adult lung models, ERJ Open Research, April 2021, European Respiratory Society (ERS),
DOI: 10.1183/23120541.00027-2021.
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