What is it about?
We have reported the data concerning increased levels of cytogenetic alterations (chromosomal aberrations and sister-chromatid exchanges) in lymphocytes from asthmatic patients. Micronuclei (MN) represent additional nuclei formed by the exclusion of chromosome fragments at mitosis, and may reflect the approximate level of chromosome breakage in cells. The MN evaluation in buccal epithelial cells seems to be much more simple method for the cytogenetic control than chromosomal analysis in lymphocytes. The aim of the study was to determine the frequencies of MN in buccal epithelial cells from allergic and non-allergic asthmatic patients.
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Why is it important?
Analysis of micronuclei is a simple method for monitoring of mutagenesis and probably predicting asthma phenotype, exacerbations and severity of the disease.
Perspectives
The MN evaluation in epithelial cells from oral mucosa seems to be much more simple method for the cytogenetic homoeostasis estimation than chromosomal analysis in lymphocytes. It is pretty simple method for monitoring of mutagenesis and probably predicting phenotype, exacerbations and severity of asthma. Further studies are needed to elucidate possible mechanisms and pathogenetic role as well as clinical significance of cytogenetic alterations including the increased MN levels in cells of asthmatic patients.
Andrey Lintsov
North-Western Mechnikov State Medical University
Read the Original
This page is a summary of: Analysis of micronuclei in buccal epithelial cells from asthmatic patients, September 2019, European Respiratory Society (ERS),
DOI: 10.1183/13993003.congress-2019.pa5212.
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