What is it about?

Serum YKL-40 and sputum YKL-40 are reflecting different processes within the airways. Serum YKL-40 might reflect a more systemic inflammation opposed to sputum YKL-40 that might reflect more local: airway inflammation.

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Why is it important?

It is thus apparent that serum YKL-40 and sputum YKL-40 might contribute to characterize a novel phenotype among severe asthmatic patients.

Perspectives

Ykl-40 might be important in a multicomponent analysis that involves structural changes in asthmatic airways and phenotyping of asthma.

Margarida Cortez e Castro
Genetic Laboratory, Lisbon Medical School

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This page is a summary of: Ykl-40 and phenotyping of severe asthma, September 2019, European Respiratory Society (ERS),
DOI: 10.1183/13993003.congress-2019.pa4084.
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