What is it about?
Alevoalr macrophages (AMϕ) are believed to play a central role in the inflammatory response characteristic of ALI,
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Why is it important?
We hypothesized that in an LPS model of ALI/ARDS, CD4-/- mice would be less susceptible to pulmonary inflammation and that this might be attributed to a defect in AMϕ.
Perspectives
Herein, we show that intra-nasal LPS results in a marked PMN accumulation in the alveolar space (BAL fluid); a response significantly blunted in CD4-/- mice. We also provide evidence that AMФ of CD4-/- mice may be functionally compromised. Using immunofluorescence microscopy, we show that AMФ isolated from CD4-/- mice have a reduced capacity for phagocytosis of microbeads. Further studies are warranted to determine whether secretions of cytokines and/or chemokines are affected in AMϕ of CD4-/- mice.
Dr. Nuha Khalid Alekhmimi
Inaya Medical College
Read the Original
This page is a summary of: Role of alevoalr macrophages and CD4 in ALI/ARDS in mice, September 2019, European Respiratory Society (ERS),
DOI: 10.1183/13993003.congress-2019.pa3863.
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