What is it about?
The authors raise their concern on methods and findings of a randomized controlled trial conducted to treat latent TB in adults over 50 years of age in China.
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Why is it important?
Although there were concerns on methodological aspects of the trial, attention is called to the need for safer regimens to treat LTBI especially in those with higher risk for adverse events, such as adults over 50.
Perspectives
4 months of Rifampicin is the safest regimen, with equivalent effectiveness than 9 months of isoniazid.
Anete Trajman
Federal University of Rio de Janeiro
Read the Original
This page is a summary of: New short regimens for latent tuberculosis treatment: safety first!, European Respiratory Journal, December 2018, European Respiratory Society (ERS),
DOI: 10.1183/13993003.02180-2018.
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Resources
Short-course regimens of rifapentine plus isoniazid to treat latent tuberculosis infection in older Chinese patients: a randomised controlled study
Clinical trial on modified 3HP regimen for LTBI in adults over 50 years of age.
Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults
Randomized controlled trial on a safer regimen to treat LTBI in adults
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