Outdoor air pollution, oxidative stress and asthma in adults

What is it about?

Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. One biological mechanism proposed to partly explain the association between outdoor air pollution and asthma is oxidative stress. Our aim was to study the associations between long-term exposure to outdoor air pollution, asthma and exhaled 8-isoprostane, a biomarker related to oxidative stress, in adults.

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Why is it important?

For the first time in adults, we found associations between long-term exposures to outdoor air pollution, exhaled 8-iso concentration and current asthma. Traffic intensity and ozone exposure were significantly associated with an increased risk of current asthma. Exhaled 8-iso concentration was positively and significantly associated with current asthma. Among participants without asthma, exhaled 8-iso concentration significantly increased with fine particulates (PM2.5) exposure, and decreased with yearly ozone and summer ozone exposures.

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