What is it about?
Oxygen administration inhibits spontaneous and ANP-stimulated lipolysis in adipose tissue in severe COPD. Severe chronic obstructive pulmonary disease (COPD) is a progressive disease associated with excessive mortality; however, mechanisms driving disease progression remain unclear. A pro-inflammatory state, metabolic impairments and respiratory muscle weakness contribute to deterioration of lung function. Furthermore, a poor COPD prognosis appears to be associated with unintentional weight loss, which has been observed in ∼50% of severe COPD patients.
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Why is it important?
Links between COPD, Diabetes, Sleep Apnea, Lipolysis/Lipogenesis and Obesity could be better understood.
Perspectives
This paper attempts to elucidate the association between COPD, ANP-stimulated (Atrial Natriuretic Peptide) lipolysis and weight loss.
Mr Sumeet Gulati
International Clinical Research Center, St. Anne’s University Hospital Brno, Pekarska 53, 656 91, Brno, Czech Republic
Read the Original
This page is a summary of: The effect of hypoxia and re-oxygenation on adipose tissue lipolysis in COPD patients, European Respiratory Journal, September 2016, European Respiratory Society (ERS),
DOI: 10.1183/13993003.00602-2016.
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