What is it about?
PIZ alpha-1 antitrypsin deficient children with normal lung function and liver parameters show increased systemic oxidative stress caused by low catalase activity and reduced glutathione levels which leads to accelerated telomere shortening.
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Why is it important?
It opens up a new rationale for the use of antioxidant therapies in the disease.
Perspectives
For the first time we showed an increased oxidative stress in healthy Alpha-1 antitrypsin deficiency children. As mentioned before antioxidant therapies might be of help to treat these patients.
Francisco Dasí
Fundación Investigación Hospital Clínico Valencia. IIS INCLIVA
Read the Original
This page is a summary of: Accelerated telomere attrition in children and teenagers with α1-antitrypsin deficiency, European Respiratory Journal, July 2016, European Respiratory Society (ERS),
DOI: 10.1183/13993003.00176-2016.
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