Type I and III Interferon Responses to Respiratory Viruses in paediatric asthma

What is it about?

Type I and III Interferon Responses are important anti-viral immune Responses. To analyze the influence of Rhinovirus and other respiratory viruses in nasopharyngeal fluid (NPF) on the interferon type I and III responses like IFN-α and IFN-λ and their signal transduction, in cohorts of pre-school children with and without Asthma at baseline and during exacerbation of the disease.

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Why is it important?

Previous studies showed defective RV-interferon responses in bronchoalveolar lavage fluid and bronchial epithelial cells from asthmatic patients. Howerever since Interferon Responses are upregulated soon after Infection, it is important to analyze them also during disease exacerbations.