What is it about?
Sepsis is an inflammatory and immune response to microbial invasion that produces organs injury developed to systemic inflammatory respon seyndrome due to organs dysfunction. Sepsis is the indirect risk factor which can developed to ARDS. The most critical point for best prognosis is to diagnose the infection at its early stage, therefore, we need a novel sensitive and rapid method for screening is necessary for sepsis detection.
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Why is it important?
In this study we designed a paper-based sensing platform for the detection of a number of expecting sepsis biomarkers such as, MMP9, α9β6 integrins, integrons RI Class1 and R2 Class 2 secreted during treated mice with FIP for 1h, 2h, 4h, and 20h (early /severe sepsis). Later on, we developed a multiplexing paper-based biosensor after adding BAL collected from septic mice on it, in order to target sepsis biomarker by cleavage of the four multiplex paper based peptides with comparison blood cultures of septic mice samples.
Perspectives
In this study we designed a paper-based sensing platform for the detection of a number of expecting sepsis biomarkers such as, MMP9, α9β6 integrins, integrons RI Class1 and R2 Class 2 secreted during treated mice with FIP for 1h, 2h, 4h, and 20h (early /severe sepsis). Later on, we developed a multiplexing paper-based biosensor after adding BAL collected from septic mice on it, in order to target sepsis biomarker by cleavage of the four multiplex paper based peptides with comparison blood cultures of septic mice samples.
Dr. Nuha Khalid Alekhmimi
Inaya Medical College
Read the Original
This page is a summary of: Paper-based biosensor for the detection of sepsis murine using MMP9 and a9ß6, integrons RI Class1 and R2 Class 2 peptides, March 2021, European Respiratory Society (ERS),
DOI: 10.1183/23120541.lsc-2021.65.
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