Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis

Kentaro Takahashi, Stelios Pavlidis, Francois Ng Kee Kwong, Uruj Hoda, Christos Rossios, Kai Sun, Matthew Loza, Fred Baribaud, Pascal Chanez, Steve J. Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Sven-Eric Dahlen, Norbert Krug, Thomas Sandstrom, Dominic E. Shaw, Rene Lutter, Per Bakke, Louise J. Fleming, Peter H. Howarth, Massimo Caruso, Ana R. Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Ratko Djukanovic, Peter J. Sterk, Yike Guo, Ian M. Adcock, Kian Fan Chung
  • European Respiratory Journal, April 2018, European Respiratory Society (ERS)
  • DOI: 10.1183/13993003.02173-2017

What is it about?

We have analysed the genes and proteins in the lungs of people suffering from severe asthma, particularly those who were previously smokers and those who are currently smoking. Those who were currently smoking could be distinguished from those who were previously smokers by having different amounts of proteins measured in the sputum. These proteins are linked to inflammation with neutrophils and to the protective functioning of the surface lining cells of the airway tubes.

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http://dx.doi.org/10.1183/13993003.02173-2017

The following have contributed to this page: fan Chung and Dr Massimo Caruso