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Proteomic analysis of the small extracellular vesicles called exosomes purified from plasma of progressive leukemic patients allowed us to identify S100-A9 protein, at progression times. We have shown in turn that S100-A9 loaded exosomes are able to activate canonical NF-kB pathway, thus promoting disease progression.
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This page is a summary of: S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression, Blood, June 2017, American Society of Hematology,
DOI: 10.1182/blood-2017-02-769851.
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