What is it about?
We show that leukemic cells can resist to chemotherapy by increasing their energetic level after taking up mitochondria from their environment
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Why is it important?
Our findings highlight a new resistant mechanism that is used by leukemic cells to escape treatments and produce relapse.
Perspectives
The understanding this new mode of resistance and the identification of the molecular players involved in the mitochondrial transfer could help define new therapeutical strategies that will cut the leukemic supports coming from their environment.
Peyron Jean-Francois
C3M INSERM
Read the Original
This page is a summary of: Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy, Blood, June 2016, American Society of Hematology,
DOI: 10.1182/blood-2015-07-655860.
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