What is it about?
An 11-month-old male who presented with acute gastroenteritis, seizures, altered mental status and hypernatremia was found to have central pontine and extrapontine myelinolysis. He received 5 days of high-dose methylprednisolone with rapid recovery of his cognitive function and neurological examination.
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Why is it important?
Osmotic demyelination of infancy may leave children with a significant neurological deficit. More than 50% of children may die of their disease within days to weeks of the onset of neurological symptoms.
Perspectives
High dose steroid is safe to use in infancy and is associated with favorable neurological outcome.
Dr Lalit Bansal
Nicklaus Children's Hospital
Read the Original
This page is a summary of: Therapeutic Effect of Steroids in Osmotic Demyelination of Infancy, Child Neurology Open, January 2018, SAGE Publications,
DOI: 10.1177/2329048x18770576.
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