What is it about?
We have built a platform which uses an acoustic pulse to fire microdroplets of liquid sample out of a standard microtitre plate, through a charge field into a mass spectrometer. This enables us to load samples at a rate of 10,000 per hour. The samples are ionized using a standard electrospray modality ensuring a wide range of analytes can be ionized.
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Why is it important?
This platform enables very high throughput loading of samples into a standard mass detector. The throughput makes this platform ideal for high-throughput screening. The ability to measure directly the conversion of substrate to product in a label free system offers many advantages including reduction in cost, improved data quality and reduction in screening artefacts. There are a significant number of potential applications for this technology both within and beyond biomedical research.
Perspectives
Read the Original
This page is a summary of: Novel Acoustic Loading of a Mass Spectrometer, SLAS TECHNOLOGY, February 2016, SAGE Publications,
DOI: 10.1177/2211068215619124.
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Resources
AstraZeneca Develops Breakthrough Acoustic Dispensing with Mass Spectrometry for Ultra High-Throughput Screening
An introduction to the novel acoustic platform developed by AstraZeneca and Labcyte Inc.
Development of a novel acoustic loading system for mass spectrometry
A presentation around the development of a novel acoustic loading system for mass spectrometry
Contributors
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