Pilot study of orphenadrine as a novel treatment for muscle cramps in patients with liver cirrhosis

What is it about?

Muscle cramps markedly affect the quality of life in cirrhotic patients with no available highly effective treatment. The aim of this study was to assess the safety and efficacy of orphenadrine in the treatment of muscle cramps in cirrhotic patients. Methods: The study enrolled 30 liver cirrhosis patients complaining of frequent muscle cramps (3 per week), who were randomized to receive either orphenadrine 100 mg or calcium carbonate 500 mg twice daily as a control for one month. Severity, frequency, and duration of the muscle cramps were assessed before and after treatment as well as recurrence after washout of the drug for two weeks. Side effects were recorded.

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Why is it important?

This is the first study to assess the efficacy and safety of orphenadrine as a novel treatment of muscle cramps in patients with liver cirrhosis.

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