What is it about?
Tranexamic acid(TXA) , a synthetic antifibrinolytic drug, is effective as a treatment for serious hemorrhage. Significant acute gastrointestinal bleeding may have a poor outcome despite routine medical and endoscopic treatment. 410 patients with proven acute gastrointestinal bleeding received conventional therapy in addition to intravenous TXA with and without topical TXA . Urgent endoscopy rate was the lowest in patients that received both topical and intravenous TXA. . TXA can aid in changing an urgent endoscopy to an elective procedure, with better outcomes for both physicians and patients.
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Why is it important?
Gastroenterologists have some problems with doing urgent endoscopy , according to adverse effect of sedation and doing difficult endoscopy .We can lower urgent endoscopy rate with adminesteration of TXA.
Perspectives
Control of acute significant gastrointestinal bleeding by medical and/or endoscopic treatment modalities can lower morbidity and mortality in this patients.
Marjan Mokhtare
Iran University of Medical Sciences
Read the Original
This page is a summary of: Comparison of the efficacy of intravenous tranexamic acid with and without topical administration versus placebo in urgent endoscopy rate for acute gastrointestinal bleeding: A double-blind randomized controlled trial, United European Gastroenterology Journal, June 2017, SAGE Publications,
DOI: 10.1177/2050640617714940.
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