Risk factors for adverse drug reactions in pediatric inpatients: a systematic review

What is it about?

The systematic review proposed by this study with focused on the identification the risk factors for ADRs in children during the hospital stay will present to the scientific community not only the factors involved in this event type as also will show a critique on the reality of the prospective methodology applied in these publications. Therefore, we identified here, information biases, generally, associated with retrospective studies, as also methodological flaws, which although not change the results presented by the authors, demonstrate recklessness during the tabulation and assessment of data.

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Why is it important?

This review can serve as a basis for new publications, as much in methodology as in writing and formulating new research. In addition, the quality assessment of studies, guarantees our results the better reliability, because includes only the studies of good quality based on the Newcastle-Ottawa scale, well diffused in scientific circles. Finally, our review, despite including fewer manuscripts: i) is more specific than others systematic reviews about the subject; ii) details the analysis type (if uni-, bi- or multivariate); iii) uses a quality assessment methodology already known; iv) operates in the error correction resulting from the calculations used in the included studies; v) performs a critical evaluation based on the method employed and vi) incorporates a greater range of keywords in the search.