Rifampicin and isoniazid plasma concentrations in relation to adverse reactions in tuberculosis patients: a retrospective analysis

What is it about?

High concentrations of anti-tuberculosis drugs have been associated with many adverse drug reactions (ADRs). to examine the plasma concentrations of rifampicin and isoniazid in patients with and without ADRs, we retrospectively analyzed therapeutic drug monitoring data of patients treated with anti-TB drugs. The results obtained showed that the concentrations above the therapeutic range in patients with and without ADRs were not reached for RMP, but were common for INH. Correlation between concentrations and doses has not been established for RMP or INH. High INH concentrations showed no association with sex, age, liver injury or renal or diabetes.

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Why is it important?

High plasma concentrations can be associated with many adverse drug reactions (ADR), and in some instance it can be reduced by dose adjustment. monitoring the anti-TB drug concentrations drugs is not commonly used in the optimization of TB treatment. However, it can provide considerable information for the clinician to enhance drug efficacy and minimize occurrence of ADR.