A rapidly expanding calvarial Langerhans cell histiocytosis with low Ki-67

What is it about?

We describe an unusual case of rapidly progressive calvarial Langerhans cell histiocytosis with a painful and tender mass in a 27-year-old man that created diagnostic and therapeutic challenges.

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Why is it important?

Even though the clinical and MRI findings may resemble an infection, rapidly expanding calvarial localised LCH should also be keptin mind in the differential diagnosis in an adult when a destructive skull lesion and peripheral and/or septal enhancing extra-axial soft tissue component is present.