What is it about?
Sulfate is an important anion in biological systems. We have shown for the first time that small molecules can bind to sulfate and allow it to diffuse across lipid bilayer membranes. This was previously thought impossible as sulfate is very strongly bound to water. We have used 33S NMR experiments to confirm sulfate transport.
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Why is it important?
We define rules for determining which of a molecule's conformational options will be adopted in its crystal structure. This is important in crystal engineering, to anticipate crystal packing and engineer crystals to exhibit targetted structures and properties. Two significant findings are that: a) molecules often do not adopt their lowest energy conformer in the solid state and b) we identify and quantify a preference for molecules to adopt extended conformations in the solid state
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to rare disease groups contacting me and ultimately to a greater involvement in rare disease research
yu lin
Read the Original
This page is a summary of: The Role and Molecular Mechanism of Long Nocoding RNA-MEG3 in the Pathogenesis of Preeclampsia, Reproductive Sciences, January 2018, SAGE Publications,
DOI: 10.1177/1933719117749753.
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Contributors
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