What is it about?
Cardio-oncology is a new and rapidly expanding field that merges cancer and cardiovascular disease. Cardiovascular disease is an omnipresent side effect of cancer therapy; in fact, it is the second leading cause of death in cancer survivors after recurrent cancer. It has been well documented that many cancer chemotherapeutic agents cause cardiovascular toxicity.
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Why is it important?
The underlying cause of cancer therapy-induced cardiovascular toxicity is largely unknown. With an increasing number of cancer patients, as well as extended life expectancy, understanding the mechanisms underlying cancer therapy induced cardiovascular disease is of the utmost importance to ensure that cancer is the only disease burden that cancer survivors have to endure.
Perspectives
Damage-associated molecular patterns (DAMPs) may play a role as an underlying contributor to cancer therapy-induced cardiovascular toxicity.
Nicole Klee
Medical College of Georgia at Augusta University
Read the Original
This page is a summary of: Out of the frying pan and into the fire: damage-associated molecular patterns and cardiovascular toxicity following cancer therapy, Therapeutic Advances in Cardiovascular Disease, September 2017, SAGE Publications,
DOI: 10.1177/1753944717729141.
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