domiphen release mechanism in poly L-lactic acid electrospun fibers

What is it about?

Anti-bacteria cantionic surfactant could be complxed within poly L-lactic acid by solution and emulsion electrospinning, due to which, the release profiles were different, espacially under degradation of proteinase K. The differences between release profiles are based on domiphen exisiting poistion after two different complexing methods. After solution electrospinning, domiphen molecules existed on or near the surface of the fibers, while after emulsion electrospinning, part of domiphen molecules existed on or near the surface of the fibers, and part domiphen molecules existed around the core-sheath surface.

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Why is it important?

There have been a lot of studies about release profiles of small molecules-loaded/complexed polymer electrospun fibers. However, the comlpexed fibers of previous studies are almost with the third ingredient complexed, which made it very difficult to understand the small molecules existing positions which is right a key factor affecting the release bahavior of these small molecules. In our studies, there were only two ingredients domiphen and poly L-lactic acid which situation made it considerable simple to study the complexing position. For the first tim, we adapted enzyme degradation-release profiles analysis method to study materials complexing in electrospun fibers.

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