What is it about?
Urinary Angiotensinogen (AGT) is known to demonstrate intrarenal RAAS. The study investigated whether HCTZ increased or decreased urinary AGT excretion in patient with CKD.
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Why is it important?
Similar to "salt-restriction diet", HCTZ also decreased intrarenal RAAS.
Perspectives
Further study is needed whether HCTZ mono therapy can decrease intrarenal RAAS activity.
Michio FUKUDA
Nagoya City University Graduate School of Medical Sciences
Read the Original
This page is a summary of: Addition of hydrochlorothiazide to angiotensin receptor blocker therapy can achieve a lower sodium balance with no acceleration of intrarenal renin angiotensin system in patients with chronic kidney disease, Journal of the Renin-Angiotensin-Aldosterone System, June 2016, SAGE Publications,
DOI: 10.1177/1470320316652032.
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