What is it about?
Haloanilines have been extensively applied in the manufacture of azo-dyes, agrochemicals, pharmaceuticals, rubber, and many other industrial chemicals. We have shown that tosylation provided a promising solution for HPLC separation of three groups of isomeric haloanilines (chloroanilines, fluoroanilines and bromoanilines) and ESI-MS/MS based differentiation of them. We have also performed mechanistic investigation on the difference in MS/MS of the o-, m- and p-haloanilines by theoretical calculation.
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Why is it important?
Differentiation of the isomeric haloanilines still remains a challenging and necessary analytic task. Our finding show that tosylation provided a promising solution for differentiation of these isomers, with HPLC separation and ESI-MS/MS based differentiation. The stability of the ion-neutral complex is a key factor for the difference in these MS.
Perspectives
We hope this article provides a promising solution for simultaneous and accurate quantitation of isomeric haloanilines.
Kezhi Jiang
Hangzhou Normal University
Read the Original
This page is a summary of: Differentiation of isomeric haloanilines by tosylation in combination with electrospray ionization mass spectrometry, European Journal of Mass Spectrometry, February 2018, SAGE Publications,
DOI: 10.1177/1469066718757587.
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