What is it about?
We propesed that formation of [M−H]+ is attributed to the ion-molecule reaction of M with the protonated ESI solvent molecule (e.g. CH3OH2+). The competing ionization processes leading to anomalous [M−H]+ and the regular [M+H]+ were significantly affected by the concentration of formic acid in the ESI solvent and the proton affinity of the N atom.
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Why is it important?
We first propesed the mechanistic formation of [M−H]+ in ESI as a result of the ion-molecule reaction of M with the protonated ESI solvent molecule (e.g. CH3OH2+), which can avoid making mistakes on the molecular weight and isotopic distribution of the relevant analytes.
Perspectives
This work was a painful exploration of the mechanistic formation of the unusual ion [M−H]+ in ESI analysis of N-(1,3-diphenylallyl)benzenamines. But it leads to a reasonable explanation for the unusual ionization mode and satisfactory results.
Kezhi Jiang
Hangzhou Normal University
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This page is a summary of: Two competing ionization processes in ESI-MS analysis of N-(1,3-diphenylallyl)benzenamines: formation of the unusual [M−H]+ ion versus the regular [M+H]+ ion, European Journal of Mass Spectrometry, July 2017, SAGE Publications,
DOI: 10.1177/1469066717717228.
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