What is it about?
As our understanding of cancer's causes and cures grows, cancer screening and detection have not. Biomarkers offer great potential for cancer screening, but only to the extent they are interpreted correctly. Screening for more biomarkers does not improve accuracy. Just counting the number of disease-related biomarkers positive "hits" offers equivocal information. This paper formalises a method for improving accuracy with fewer biomarkers needed to screen for oral squamous cell carcinoma (OSCC).
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Why is it important?
Some locations have challenging expenses and logistics for collection, preservation, storage, and testing of samples. Using fewer biomarkers to reach a confident triage decision would save expenses and save lives by reducing screening complexity.
Perspectives
The science of screening needs to keep pace with the discovery of new disease indicators and treatments to control unnecessary expenses and improve accuracy.
J. Michael Menke
A. T. Still Research Institute
Read the Original
This page is a summary of: More Accurate Oral Cancer Screening with Fewer Salivary Biomarkers, Biomarkers in Cancer, January 2017, SAGE Publications,
DOI: 10.1177/1179299x17732007.
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