What is it about?
The objective of this study was to evaluate a low-molecular-weight heparin (LMWH) calibrated anti-Xa assay for the quantification of rivaroxaban and apixaban plasma concentration in emergency
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Why is it important?
To our knowledge, oral anti-Xa assay is not readily available in all hospital laboratories. This could be related to the cost of the assay, which requires specific calibration and controls for each drug. However, in clinical practice, determination of drug concentration is necessary with bleeding or emergency procedure.
Perspectives
In the absence of a specific test, LMWH-calibrated anti-Xa assay could be used to determine the presence of and evaluate oral anti-Xa plasma concentration inhibitors before performing emergency surgical procedures. It could also be used for the indication for a reversal agent. However, these initial findings require confirmation using other chromogenic- calibrated anti-Xa assays.
Paul Billoir
Rouen University Hospital Vascular Hemostasis Unit
Read the Original
This page is a summary of: Anti-Xa Oral Anticoagulant Plasma Concentration Assay in Real Life: Rivaroxaban and Apixaban Quantification in Emergency With LMWH Calibrator, Annals of Pharmacotherapy, October 2018, SAGE Publications,
DOI: 10.1177/1060028018811657.
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