Outcomes of alveolar graft with BMP

What is it about?

Objective: to evaluate the influence of cleft type and width, canine eruption stage and surgeon on the outcomes of alveolar graft with rhBMP-2. Interventions: 90 individuals were submitted to alveolar graft with rhBMP-2. Periapical radiographs were obtained before and 6 months after surgery. Surgeries were performed by 4 surgeons. The alveolar grafts were assigned as success or failure by three raters. Permanent canines adjacent to the defect were assigned as erupted and not erupted. The greatest cleft width was measured on preoperative periapical radiographs. Main outcome measures: The influence of four variables (cleft type, cleft width, canine eruption phase and surgeon) on the outcome of alveolar graft was analyzed by statistical tests. Results: all variables presented significant influence on alveolar graft outcome. Conclusion: the type and width of CLP, the eruption of permanent canines as well as the surgeon influenced the outcome of alveolar graft surgeries performed with rhBMP-2.

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Why is it important?

Alveolar grafts are protocolally performed by centers specialized in the rehabilitation of patients with cleft lip and palate, however, their success rates vary widely. Several factors are related to this variability, but there is great controversy in the literature about it. Research on the topic helps increase the success rates of this surgery.