What is it about?
Dysregulation of long non-coding RNAs has been shown to promote tumor growth and metastasis in several cancers. In this study, we investigated the expression of 11 selected long non-coding RNAs that are associated with cell proliferation, metastasis, and tumor suppression in oral squamous cell carcinomas and normal tissues by quantitative real-time polymerase chain reaction.
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Why is it important?
In oral squamous cell carcinomas, for the first time, we observed linc-RoR overexpression, downregulation of miR-145-5p, and overexpression of c-Myc, Klf4, Oct4, and Sox2, suggesting the existence of linc-RoR-mediated competing endogenous RNA network in undifferentiated tumors and its prognostic value to predict the therapeutic response.
Perspectives
This study shows that lncRNAs were dysregulated in oral SCCs, and majority of them were significantly associated with tobacco chewing/smoking. The sponging of miR-145-5p by overexpressed linc-RoR may relieve the post-transcriptional control of target genes c-Myc, Klf4, Oct4, and Sox2 (stemeness transcription factors), which facilitates the maintenance of undifferentiated state. Patient treatment follow-up data showed a significant importance of linc-RoR with therapeutic response and recurrence suggesting that linc-RoR is a biomarker for poor prognosis.
Dr ArunKumar Ganesan
Read the Original
This page is a summary of: Expression profiling of long non-coding RNA identifies linc-RoR as a prognostic biomarker in oral cancer, Tumor Biology, April 2017, SAGE Publications,
DOI: 10.1177/1010428317698366.
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