What is it about?
Many diseases are sex-specific. To balance the genetic effect between two sexes, X chromosome inactivation occurs in most of X-linked genes by silencing one copy of two X chromosomes in females and dosage compensation is achieved. This work focuses on locating the disease positions on X chromosome by considering dosage compensation.
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Why is it important?
Unlike autosomes, X chromosome has its own characteristics. Females have two copies of X chromosomes but males only have one. To balance the genetic effect between two sexes, X chromosome inactivation occurs in most of X-linked genes by silencing one copy of two X chromosomes in females. Our finding shows that our proposed method generally outperforms the existing methods in terms of controlling the size and the test power by incorporating dosage compensation.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. In addition, I hope that this article makes people find more loci which are truly associated with the diseases under study.
Professor Ji-Yuan Zhou
Southern Medical University
Read the Original
This page is a summary of: A robust and powerful test for case–control genetic association study on X chromosome, Statistical Methods in Medical Research, September 2018, SAGE Publications,
DOI: 10.1177/0962280218799532.
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