Detection of imprinting effects for qualitative traits on X chromosome based on nuclear families

What is it about?

Some diseases are reported to be associated with the imprinted genes on X chromosomes, such as Turner’s syndrome. However, no method is available in the literature to test for imprinting effects on X chromosome. As such, in this article, we proposed a novel test statistic for such a task.

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Why is it important?

Methods for detecting imprinting effects have been developed primarily for autosomal markers. So far, we are not aware of any statistical test for imprinting effects on X chromosome, although imprinting tests on autosomes have been developed for more than 15 years. Therefore, it is necessary to suggest methods for detecting such imprinting effects. In this article, the parental-asymmetry test on X chromosome (XPAT) is developed to test for imprinting for qualitative traits in the presence of association, based on nuclear families. The results show that XPAT is valid and powerful in the detection of imprinting effects on X chromosome.

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