What is it about?
HNK-102 is a newly synthesized oxime, found to be more effective compared to that of 2-PAM, as an antidote, against Nerve Agents poisoning in Swiss mice. In the recent past, we have reported its superiority over 2-PAM against Dichlorvos (an insecticide), DFP and frequently misused sarin (a nerve agent). The present study reports its better antidote action against tabun and soman (nerve agents).
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Why is it important?
Till date, no single oxime was found to be effective as antidote, against most of the nerve agents. For example, 2-PAM was not found to be effective against soman (a nerve agent) and dichlorvos (an insecticide) and HI-6 not effective against tabun poisoning. However, HNK-102 was found to be better antidote in terms of protection and also effective against all the above poisons in Swiss mice.
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This page is a summary of: In vivo protection studies of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl) acetamide derivatives (HNK oximes) against tabun and soman poisoning in Swiss albino mice, Human & Experimental Toxicology, January 2017, SAGE Publications,
DOI: 10.1177/0960327116685888.
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