What is it about?
HNK-102, a newly synthesized oxime, was found to be more effective compared to that of presently used 2-PAM, as an antidote against acute Sarin (one of the Nerve Agents) poisoning in Swiss albino mice.
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Why is it important?
HNK-102, a newly synthesized oxime, was found to be more effective and less toxic compared to existing 2-PAM.
Perspectives
Attempts are being made globally to identify and develop an oxime antidote for the treatment of organophosphorous poisoning e.g. insecticides and Nerve Agents. In order to achieve it, a series of oximes were synthesized and HNK-102 was found to be more effective and less toxic compared to existing 2-PAM in vivo.
Dr Pravin Kumar
Defence R&D Establishment
Read the Original
This page is a summary of: In vivo protection studies of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl) acetamide derivatives against sarin poisoning in mice, Human & Experimental Toxicology, March 2016, SAGE Publications,
DOI: 10.1177/0960327116637109.
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