What is it about?
Hypoxia induced signaling is a key trigger for tissue regeneration. Here we evaluated a novel clay based gel which can stimulate this mechanism in vitro. We assessed the response of cells fron the periodontal soft tissue upon incubation with the synthetic clay with and without supplementation with hypoxia mimetic agents.
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Why is it important?
The development of novel regenerative strategies for periodontal regeneration is of high clincal releveance. These strategies rely on a feasible biocompatible scaffold material. Synthetic clay based hypoxia mimetic gels represent a promising candidate. However, the response of oral cells to such a hydrogel is unknown,
Perspectives
Working on this novel aplication of syntheic clay was an great pleasure and we gained much know-how on the application of synthic clay-based hydrogels. The authors thank Manuela Pensch for skillful technical assistance. The authors deny any conflict of interest. Our research was supported by the Osteology Foundation (10-063). Anna Müller received the research fellowship “Wissenschaftsstipendium für Waldviertler WissenschaftlerInnen mit sozialer Kompetenz Wissenschaft – solide wie Waldviertler Granit” by the GEA Akademie (Schrems, Austria).
Priv.-Doz. Hermann Agis
Medizinische Universitat Wien
Read the Original
This page is a summary of: The impact of clay-based hypoxia mimetic hydrogel on human fibroblasts of the periodontal soft tissue, Journal of Biomaterials Applications, February 2019, SAGE Publications,
DOI: 10.1177/0885328218821042.
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