antibacterial polymer (PHMB) encapsulated in Nanoliposomes

What is it about?

Liposomes are nontoxic, biodegradable, biocompatible, bioavailable, colloidal assembling structures and fluid-filled vesicles that can entrap a widespread range of materials and drugs.6–9 Liposomes are used as novel carrier for intracellular delivery of antimicrobial agents penetrating the normal epithelial cells. Poly(hexamethylene biguanide) (PHMB) is commercially available in the form of powder or water-soluble hydrochloride as a mixture of oligomers of different chain lengths.20,21 It is a member of the polymeric guanidine family22 being applied as preservatives in pharmaceutical, broad-spec- trum antiseptic with excellent tolerance along with a low-risk profile in medicine.23 They also uti- lize in clinical applications such as a treatment against Gram-positive and Gram-negative bacteria, fungi, protozoa, and biofilms.24,25 These can be used in the treatment of third-degree burns and rinsing of joint cavity in the case of empyema.

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Why is it important?

Antibacterial properties of PHMB

Perspectives