What is it about?
OMS in infants and toddlers is often paraneoplastic due to neuroblastoma. Even with resection of neuroblastoma, the child generally needs prolonged and intensive immunosuppression. We followed a group of children with OMS and assessed development, comparing them to a similar group treated about 10-15 years ago. Recently treated OMS patients had overall better developmental and behavioral outcome, although many still have some deficits. The major treatment difference was the addition of rituximab, along with ACTH and IVIG.
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Why is it important?
More aggressive immunosuppression appears to improve outcome and prevent some of the chronic cognitive and behavioral deficits seen in children with OMS.
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This page is a summary of: Effect of Increased Immunosuppression on Developmental Outcome of Opsoclonus Myoclonus Syndrome (OMS), Journal of Child Neurology, October 2014, SAGE Publications,
DOI: 10.1177/0883073814549581.
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