OXPHOS Deficits in Schizophrenia

What is it about?

This review aricle summarizing evidence obtained by different methodological strategies for deficits in OXPHOS, specifically complex I, in schizophrenia. In addition OXPHOS potential effect on mitochondrial crosstalk with the cell, neuronal development, connectivity and plasticity is described.

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Why is it important?

Complex I of the OXPHOS has been shown as a site of interaction for both dopamine (DA) and antipsychotic drugs,further substantiating its role in the pathology of SCZ. Understanding the role of mitochondria and the OXPHOS in particular may encourage new insights into the pathophysiology and etiology of this debilitating disorder and may ultimately lead to the unravelling of new biomarker and traget for treatment .